Esomeprazole Magnesium 20mg Tablet is used to treat stomach and intestinal ulcers, providing relief from heartburn, pain, and chest pain caused by acid reflux disease (Gastroesophageal reflux disease). It is also effective in treating Zollinger-Ellison syndrome, a condition characterized by increased stomach acid production due to a tumor. Additionally, it helps eradicate infections caused by the bacteria H. pylori, which, if untreated, can lead to ulcers.
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Avoid or limit the consumption of alcohol while taking Esoral 20mg Capsule because it might increase the amount of acid in your stomach than normal which can irritate your stomach lining and worsen your symptoms.
This medicine cannot be used by pregnant women unless necessary. Consult your doctor before taking this medicine.
It is not known if Esoral 20mg Capsule passes into breastmilk. Therefore, if you are breastfeeding, consult your doctor to understand the risks and benefits associated with this medicine.
Do not drive or operate any heavy tools or machines if you experience dizziness and blurred vision after taking Esoral 20mg Capsule. Consult your doctor before taking Esoral 20mg Capsule.
Esoral 20mg Capsule should be used with caution in patients with severe kidney problems. Consult your doctor before taking Esoral 20mg Capsule.
Esoral 20mg Capsule should be used with caution in patients with severe liver problems. Consult your doctor before taking Esoral 20mg Capsule.
Esomeprazole in Esoral 20mg Capsule works by reducing the intake of certain ions in the stomach wall that is necessary for the production of digestive acids in the stomach, thereby lowering acid secretion.
Erosive Esophagitis is the swelling of the oesophagus, the tube that carries food from your throat to your stomach. It occurs when excess acid produced in the stomach flows back into your oesophagus, causing irritation and damage. Esoral 20mg Capsule is used to treat erosive esophagitis.
Gastroesophageal Reflux Disease (GERD) is a condition that occurs when stomach acid frequently flows back into your food pipe. The symptoms include heartburn, indigestion, difficulty in swallowing, etc. Esoral 20mg Capsule helps in the treatment of GERD by decreasing stomach acid production.
Helicobacter Pylori infection is a bacterial infection affecting your stomach and intestine caused by Helicobacter pylori. It is a very common infection that may cause ulcers in your stomach and intestine. Esoral 20mg Capsule is used in combination with antibiotics to treat and prevent Helicobacter Pylori infection.
Zollinger-Ellison Syndrome is a condition in which tumours form in the pancreas (an organ located behind the stomach) and duodenum (the first part of the small intestine). These tumours produce a hormone called gastrin which in turn causes excessive stomach acid. Esoral 20mg Capsule is used to reduce the excessive amount of acid produced in the stomach due to tumours.
Peptic ulcers are sores that are formed in the lining of your stomach and duodenum (the beginning of the small intestine). It occurs when excess acid produced in the stomach damages the protective layer of your stomach and small intestine. Esoral 20mg Capsule is used to treat ulcers of the stomach and small intestine.
Esomeprazole is a proton pump inhibitor that effectively reduces gastric acid secretion by inhibiting the H+/K+-ATPase enzyme in the gastric parietal cell. It is the S-isomer of omeprazole and provides better acid control compared to racemic proton pump inhibitors.
The capsules of esomeprazole contain enteric-coated pellets of esomeprazole magnesium, which enhances its absorption. Peak plasma levels are achieved around 1.5 hours after oral dosing. Increasing the dosage leads to proportionate increases in peak plasma levels and the area under the plasma concentration-time curve (AUC). With repeated once-daily dosing, the systemic bioavailability of esomeprazole is around 90%.
Esomeprazole is highly bound to plasma proteins (97%) and has a constant volume of distribution at a steady state. It undergoes extensive metabolism in the liver, mainly through the CYP2C19 enzyme, with no anti-secretory properties found in its metabolites.
The plasma elimination half-life of esomeprazole is approximately 1-1.5 hours, and less than 1% of the parent drug is eliminated in the urine. About 80% of an oral dose of esomeprazole is excreted in the urine as inactive metabolites, with the remainder detected in the feces as inactive metabolites.
In combination therapy, esomeprazole is administered along with clarithromycin and amoxicillin for antimicrobial purposes. The combination therapy shows some effects on the pharmacokinetics of esomeprazole and its metabolites, but these changes are not considered clinically significant.
Esomeprazole is metabolized in the liver primarily by CYP2C19 and CYP3A4 enzymes. It does not inhibit CYPs 1A2, 2A6, 2C9, 2D6, 2E1, or 3A4, suggesting no significant interactions with drugs processed by these CYP enzymes.
No clinically significant interactions have been observed with phenytoin, warfarin, quinidine, clarithromycin, or amoxicillin when co-administered with esomeprazole.
However, esomeprazole may increase diazepam plasma levels up to 12 hours after treatment.
As esomeprazole inhibits gastric acid secretion, it may affect the absorption of drugs whose bioavailability is influenced by stomach pH, such as ketoconazole, iron salts, and digoxin.
Oral contraceptives, diazepam, phenytoin, and quinidine do not seem to affect the pharmacokinetic profile of esomeprazole.
When esomeprazole is given with clarithromycin and amoxicillin in combination therapy, the plasma levels of esomeprazole and 14-hydroxy clarithromycin rise.
It is contraindicated in patients with known hypersensitivity to Esomeprazole or to substituted benzimidazoles
Pregnancy: There are no sufficient and well-controlled studies in pregnant women regarding the use of esomeprazole. Esomeprazole is the S-isomer of omeprazole, and available epidemiologic data do not show an increased risk of major congenital malformations or other adverse pregnancy outcomes with first-trimester omeprazole use. However, in reproduction studies conducted in rats and rabbits, dose-dependent embryo-lethality was observed at omeprazole doses approximately 3.4 to 34 times an oral human dose of 40 mg (based on a body surface area for a 60 kg person).
Lactation: Esomeprazole is the S-isomer of omeprazole, and limited data suggest that omeprazole may be present in human milk. However, there are no clinical data on the effects of esomeprazole on breastfed infants or on milk production. The developmental and health benefits of breastfeeding should be considered along with the mother's clinical need for therapy and any potential adverse effects on the breastfed infant from treatment or the underlying maternal condition.
Store in a dry location at a temperature of not more than 30°C. Light and dampness should be avoided. Keep out of children's reach.
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